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IONIS PHARMACEUTICALS INC IONS

Nasdaq · stock · Pharmaceutical Preparations · website · IPO 1991-05-17 · LEI

IONIS PHARMACEUTICALS INC statistics & valuation

Market cap$13.4B
P / S14.2×
P / B27.4×
Net margin-40.4%
Return on equity-78.0%
FCF margin-33.9%
Net debt$1.4B
Enterprise value USD$14.9B
Earnings yield EBIT/EV-2.6%
Return on capital-13.9%

Market cap as of 2026-06-29. Multiples are price-derived and refreshed daily; everything else from the latest financial reports.

Profitability & efficiency

Net margin (%)
-16.20% 0.10% 45.60% 24.80% -60.90% -3.50% -45.90% -46.50% -64.40% -40.40% 2016201720182019202020212022202320242025
Gross margin (%)
2016201720182019202020212022202320242025
Operating margin (%)
-5.40% 6.00% -10.20% 32.60% -23.60% -3.70% -69.80% -44.90% -67.40% -40.40% 2016201720182019202020212022202320242025
Return on equity (%)
-60.70% 0.10% 24.90% 17.60% -59.80% -3.70% -47.10% -94.70% -77.10% -78.00% 2016201720182019202020212022202320242025
Shares outstanding
121.6M 126.1M 137.9M 153.2M 140.4M 141.2M 142.1M 144.3M 157.9M 163.3M 2016201720182019202020212022202320242025
Net debt ($)
$917.8M $909.1M $1.01B $1.44B 2016201720182019202020212022202320242025
Share buybacks ($)
2016201720182019202020212022202320242025
Return on assets (%)
-6.60% 0.00% 10.30% 8.60% -18.60% -1.10% -10.60% -12.30% -15.10% -10.80% 2016201720182019202020212022202320242025
Free cash flow margin (%)
-32.00% 27.10% 98.30% 28.00% 0.10% 2.30% -49.40% -42.10% -77.50% -33.90% 2016201720182019202020212022202320242025
Debt / equity (×)
2.08× 3.38× 2.13× 3.71× 2016201720182019202020212022202320242025
EPS ($)
-$0.50 $0.15 $2.07 $1.90 -$3.18 -$0.20 -$1.90 -$2.56 -$3.04 -$2.38 2016201720182019202020212022202320242025

Margins and returns computed from annual filings. Falling shares outstanding = buybacks; rising = dilution. Net debt = debt − cash (negative = net cash).

Key ratios (by fiscal year)

RatioFY2025FY2024FY2023FY2022FY2021FY2020FY2019FY2018FY2017FY2016
Operating margin-40.4%-67.4%-44.9%-69.8%-3.7%-23.6%32.6%-10.2%6.0%-5.4%
Net margin-40.4%-64.4%-46.5%-45.9%-3.5%-60.9%24.8%45.6%0.1%-16.2%
FCF margin-33.9%-77.5%-42.1%-49.4%2.3%0.1%28.0%98.3%27.1%-32.0%
Return on assets-10.8%-15.1%-12.3%-10.6%-1.1%-18.6%8.6%10.3%0.0%-6.6%
Return on equity-78.0%-77.1%-94.7%-47.1%-3.7%-59.8%17.6%24.9%0.1%-60.7%
Debt / equity3.71×2.13×3.38×2.08×——————
Current ratio3.838.475.907.079.753.569.977.884.805.96

Computed from company filings · US · as of 2025-12-31. Facts plus Stocktoria's own computed scores — not investment advice.