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Karyopharm Therapeutics Inc. KPTI

Nasdaq · stock · Pharmaceutical Preparations · website · IPO 2013-11-06 · LEI

Karyopharm Therapeutics Inc. statistics & valuation

Market cap$231.4M
P / S1.6×
Net margin-134.2%
FCF margin-51.6%
Return on capital-554.6%

Market cap as of 2026-06-29. Multiples are price-derived and refreshed daily; everything else from the latest financial reports.

Profitability & efficiency

Net margin (%)
-71153.90% -8036.40% -588.10% -488.10% -181.60% -59.10% -105.20% -98.00% -52.60% -134.20% 2016201720182019202020212022202320242025
Gross margin (%)
2016201720182019202020212022202320242025
Operating margin (%)
-71903.90% -8133.20% -593.00% -462.90% -159.00% -46.80% -90.50% -88.70% -82.20% -62.10% 2016201720182019202020212022202320242025
Return on equity (%)
-67.50% -99.60% -97.40% -401.00% -388.30% 2016201720182019202020212022202320242025
Shares outstanding
41.9M 49.5M 60.8M 65.4M 73.9M 75.7M 113.2M 114.9M 8.4M 18.3M 2016201720182019202020212022202320242025
Net debt ($)
-$21.2M 2016201720182019202020212022202320242025
Share buybacks ($)
2016201720182019202020212022202320242025
Return on assets (%)
-60.70% -71.50% -52.30% -67.70% -62.70% -40.60% -46.10% -59.50% -46.50% -180.80% 2016201720182019202020212022202320242025
Free cash flow margin (%)
-54844.80% -4596.80% -532.30% -467.10% -148.40% -51.20% -95.30% -63.50% -87.90% -51.60% 2016201720182019202020212022202320242025
Debt / equity (×)
2016201720182019202020212022202320242025
EPS ($)
-$2.72 -$1.65 -$2.02 -$18.79 -$14.00 -$17.93 2016201720182019202020212022202320242025

Margins and returns computed from annual filings. Falling shares outstanding = buybacks; rising = dilution. Net debt = debt − cash (negative = net cash).

Key ratios (by fiscal year)

RatioFY2025FY2024FY2023FY2022FY2021FY2020FY2019FY2018FY2017FY2016
Operating margin-62.1%-82.2%-88.7%-90.5%-46.8%-159.0%-462.9%-593.0%-8133.2%-71903.9%
Net margin-134.2%-52.6%-98.0%-105.2%-59.1%-181.6%-488.1%-588.1%-8036.4%-71153.9%
FCF margin-51.6%-87.9%-63.5%-95.3%-51.2%-148.4%-467.1%-532.3%-4596.8%-54844.8%
Return on assets-180.8%-46.5%-59.5%-46.1%-40.6%-62.7%-67.7%-52.3%-71.5%-60.7%
Return on equity66.9%41.1%105.1%992.4%155.7%-388.3%-401.0%-97.4%-99.6%-67.5%
Debt / equity————-2.12×—————
Current ratio1.121.703.375.313.744.596.017.133.007.99

Computed from company filings · US · as of 2025-12-31. Facts plus Stocktoria's own computed scores — not investment advice.