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Protagonist Therapeutics, Inc PTGX

Nasdaq · stock · Pharmaceutical Preparations · website · IPO 2016-08-11

Protagonist Therapeutics, Inc statistics & valuation

Market cap$7.8B
P / B12.8×
P / FCF139.8×
Net margin-282.8%
Return on equity-21.2%
FCF margin121.9%
Return on capital-25.4%

Market cap as of 2026-06-29. Multiples are price-derived and refreshed daily; everything else from the latest financial reports.

Profitability & efficiency

Net margin (%)
-184.20% -125.90% -33414.30% -231.10% -458.90% -479.30% -131.60% 63.30% -282.80% 2016201720182019202020212022202320242025
Gross margin (%)
2016201720182019202020212022202320242025
Operating margin (%)
-188.90% -136.70% -34857.60% -225.40% -460.00% -494.20% -156.10% 58.20% -343.60% 2016201720182019202020212022202320242025
Return on equity (%)
-42.50% -30.60% -34.60% -96.50% -23.70% -41.80% -59.10% -23.50% 40.80% -21.20% 2016201720182019202020212022202320242025
Shares outstanding
16.7M 21.1M 23.2M 27.2M 43.7M 47.8M 49.3M 57.7M 65.1M 63.6M 2016201720182019202020212022202320242025
Net debt ($)
-$23.2M 2016201720182019202020212022202320242025
Share buybacks ($)
2016201720182019202020212022202320242025
Return on assets (%)
-39.60% -22.60% -27.90% -49.80% -20.40% -36.10% -51.40% -22.10% 37.00% -19.50% 2016201720182019202020212022202320242025
Free cash flow margin (%)
16.00% -163.10% -18395.70% -254.80% -398.30% -409.80% -118.10% 42.10% 121.90% 2016201720182019202020212022202320242025
Debt / equity (×)
0.12× 2016201720182019202020212022202320242025
EPS ($)
-$1.92 -$2.71 -$2.60 -$1.39 $4.23 -$2.05 2016201720182019202020212022202320242025

Margins and returns computed from annual filings. Falling shares outstanding = buybacks; rising = dilution. Net debt = debt − cash (negative = net cash).

Key ratios (by fiscal year)

RatioFY2025FY2024FY2023FY2022FY2021FY2020FY2019FY2018FY2017FY2016
Operating margin-343.6%58.2%-156.1%-494.2%-460.0%-225.4%-34857.6%-136.7%-188.9%—
Net margin-282.8%63.3%-131.6%-479.3%-458.9%-231.1%-33414.3%-125.9%-184.2%—
FCF margin121.9%42.1%-118.1%-409.8%-398.3%-254.8%-18395.7%-163.1%16.0%—
Return on assets-19.5%37.0%-22.1%-51.4%-36.1%-20.4%-49.8%-27.9%-22.6%-39.6%
Return on equity-21.2%40.8%-23.5%-59.1%-41.8%-23.7%-96.5%-34.6%-30.6%-42.5%
Debt / equity——————0.12×———
Current ratio12.7112.4816.717.807.747.844.105.263.5512.94

Computed from company filings · US · as of 2025-12-31. Facts plus Stocktoria's own computed scores — not investment advice.