Stocktoria

Spero Therapeutics, Inc. SPRO

Nasdaq · stock · Pharmaceutical Preparations · website · IPO 2017-11-02 · LEI

Spero Therapeutics, Inc. statistics & valuation

Market cap$130.9M
P / E15.3×
P / S2.0×
P / B2.2×
Net margin12.8%
Return on equity14.5%
Return on capital10.5%
Graham number +54.4%$1.84

Market cap as of 2026-06-29. Multiples are price-derived and refreshed daily; everything else from the latest financial reports. The Graham number is Benjamin Graham's rough maximum fair value ($1.84); a green figure means the price is below it.

Profitability & efficiency

Net margin (%)
-7609.30% -1957.70% -1051.40% -335.60% -839.20% -491.90% 22.00% -142.90% 12.80% 2016201720182019202020212022202320242025
Gross margin (%)
2016201720182019202020212022202320242025
Operating margin (%)
-9916.70% -2108.60% -1079.30% -348.40% -847.90% -481.90% -78.90% 20.70% -152.90% 9.50% 2016201720182019202020212022202320242025
Return on equity (%)
-45.60% -36.00% -81.70% -59.30% -101.70% 21.30% -148.70% 14.50% 2016201720182019202020212022202320242025
Shares outstanding
0 14.4M 17.2M 19.2M 29.3M 32.4M 52.5M 53.0M 54.6M 59.0M 2016201720182019202020212022202320242025
Net debt ($)
2016201720182019202020212022202320242025
Share buybacks ($)
2016201720182019202020212022202320242025
Return on assets (%)
-185.10% -41.40% -32.30% -57.40% -51.00% -52.50% 12.50% -62.00% 12.40% 2016201720182019202020212022202320242025
Free cash flow margin (%)
-8892.20% -1977.70% -1060.50% -277.40% -922.10% 2016201720182019202020212022202320242025
Debt / equity (×)
2016201720182019202020212022202320242025
EPS ($)
-$2.91 -$1.23 $0.43 -$1.27 $0.15 2016201720182019202020212022202320242025

Margins and returns computed from annual filings. Falling shares outstanding = buybacks; rising = dilution. Net debt = debt − cash (negative = net cash).

Key ratios (by fiscal year)

RatioFY2025FY2024FY2023FY2022FY2021FY2020FY2019FY2018FY2017FY2016
Operating margin9.5%-152.9%20.7%-78.9%-481.9%-847.9%-348.4%-1079.3%-2108.6%-9916.7%
Net margin12.8%-142.9%22.0%—-491.9%-839.2%-335.6%-1051.4%-1957.7%-7609.3%
FCF margin—————-922.1%-277.4%-1060.5%-1977.7%-8892.2%
Return on assets12.4%-62.0%12.5%—-52.5%-51.0%-57.4%-32.3%-41.4%-185.1%
Return on equity14.5%-148.7%21.3%—-101.7%-59.3%-81.7%-36.0%-45.6%51.8%
Current ratio7.592.193.535.258.469.703.5810.0811.291.72

Computed from company filings · US · as of 2025-12-31. Facts plus Stocktoria's own computed scores — not investment advice.