Stocktoria

TALPHERA, INC. TLPH

Nasdaq · stock · Pharmaceutical Preparations · website · IPO 2011-02-11

TALPHERA, INC. (TLPH) earns a Piotroski F-score of 4/9 (mixed financial health). It does not currently pay a dividend. FY2025 revenue was $28,000 at a -51035.7% net margin.

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26/100
Stocktoria Quality Score · grade D
4/9
Piotroski F — financial health
Altman Z″ — distress risk
Dividend yield · no dividend

Quality score trend · recomputed for each fiscal year

Piotroski F /9
2 1 4 2 2 5 3 3 3 4 2016201720182019202020212022202320242025
Altman Z″
-5.06 -12.32 -6.27 -14.35 2016201720182019202020212022202320242025

Each year's score is computed from that year's filing — a rising Piotroski F or Altman Z″ means improving financial health, a fall is worth a look.

$1.40 as of 2026-08-01 · +159.3% 1y
$0.54$1.4052-wk
Market cap USD$53M
Net margin 5y avg-18369.1%
Return on equity 5y avg-39.5%
Beta0.76
Employees12

Analyst price target

$3.17 +126.2% vs last
· 3 analysts
target range $3.00 – $3.50

Wall Street analyst consensus — a sentiment gauge, not our scoring.

Revenue trend · last 10y · down

How it ranks in Manufacturing · percentile among 1957 companies

Piotroski Fstronger than 45%
Net marginstronger than 1%
Return on equitystronger than 21%

Percentile vs other Manufacturing companies we cover — e.g. “stronger than 90%” means only 10% score higher on that measure.

Piotroski F breakdown · 4/9 tests passed

Sector peers · similar-size Manufacturing companies compare side by side →

TickerCompanyPiotroski FAltman Z″P / ERevenue growth
TLPHTALPHERA, INC.4/9
IBOIMPACT BIOMEDICAL INC.3/9-2.38
JUNSJUPITER NEUROSCIENCES, INC.2/9
LYELLyell Immunopharma, Inc.1/9-13.93
PRFXPRF Technologies Ltd.4/9-14.88
AXIMAXIM BIOTECHNOLOGIES, INC.3/9
NTHINEONC TECHNOLOGIES HOLDINGS, INC.1/9

All Manufacturing companies →

About TALPHERA, INC.

Talphera, Inc., a specialty pharmaceutical company, focuses on the development and commercialization of therapies for use in medically supervised settings. The company's lead product candidate, Niyad, is a lyophilized formulation of nafamostat that acts as a regional anticoagulant for infusion into the extracorporeal circuit. It is also developing LTX-608, a lyophilized vial containing nafamostat for IV infusion for disseminated intravascular coagulation, acute respiratory distress syndrome, acute pancreatitis, and an anti-viral treatment; Fedsyra, an ephedrine pre-filled syringe for injection; and a phenylephrine pre-filled syringe for injection. The company was formerly known as AcelRx Pharmaceuticals, Inc. and changed its name to Talphera, Inc. in January 2024. The company was incorporated in 2005 and is headquartered in San Mateo, California.

FAQ

Is TLPH financially healthy?

TALPHERA, INC.'s Piotroski F-score is 4/9 (8–9 is excellent, 0–3 weak).

Does TLPH pay a dividend?

No, TALPHERA, INC. does not currently pay a dividend.

How profitable is TLPH?

In FY2025, TALPHERA, INC. had a net margin of -51035.7% and a return on equity of -83.9%.

What is the analyst price target for TLPH?

The average Wall-Street price target for TALPHERA, INC. is $3.17, about 126.2% above the recent price, from 3 analysts.

Is TLPH a good stock to buy?

Stocktoria doesn't give buy or sell advice, but here is the data on TALPHERA, INC.: a Piotroski F-score of 4/9. Weigh these quality and valuation signals against your own goals.

Computed from company filings · US · as of 2025-12-31. Facts plus Stocktoria's own computed scores — not investment advice.